Cancer (Oncology) Clinical Trials

• Advanced Solid Tumors
• A Phase 1/2 Research Study for Patients with Ovarian Clear Cell Carcinoma or Endometrial Carcinoma or other Advanced Solid Tumors

• Bladder Cancer
• Research study for adults at risk, diagnosed with, or being evaluated for cancer
• A research study of two immunotherapy drugs (derazantinib and atezolizumab) in patients with urothelial (bladder) cancer
• Patients with bladder cancer needed for a research study of two immunotherapy drugs (derazantinib and atezolizumab)
• A study of experimental combination of 2 drugs versus standard chemotherapy in patients with metastatic urothelial cancer
• Patients with a locally advanced or metastatic solid tumor cancers are needed for a study to research an investigational immunotherapy

• Brain Cancer
• Seeking Adults with Progressive Meningiomas
• Women with breast cancer leptomeningeal metastases are needed for a study to research an experimental cellular therapy.
• Study for Adults with Primary Central Nervous System Lymphoma (PCNSL)

• Brain Tumor
• Seeking Adults with Progressive Meningiomas
• Women with breast cancer leptomeningeal metastases are needed for a study to research an experimental cellular therapy.
• Study for Adults with Primary Central Nervous System Lymphoma (PCNSL)

• BRCA1
• Research study for ovarian cancer patients with BRCA1 mutations to compare two surgical procedures

• Breast Cancer
• Patients with a locally advanced or metastatic solid tumor cancers are needed for a study to research an investigational immunotherapy
• Women with breast cancer leptomeningeal metastases are needed for a study to research an experimental cellular therapy.
• Research study for Early Stage Breast Cancer
• Patients with metastatic breast cancer are needed for a study to research an investigational drug combination involving an immunotherapy and a cellular therapy.
• Adults with lung, breast, or ovarian/fallopian tube cancers invited to be in a nerve disorder research study.
• Adults with metastatic breast cancer invited to be in a research study testing an oncolytic reovirus and an immunotherapy drug in combination with chemotherapy.
• Adults with HER2 (Human Epidermal Growth Factor Receptor 2)-positive early breast cancer with residual invasive disease following preoperative chemotherapy and surgery invited to be in a research study
• The University of Virginia Cancer Center is seeking women age 65+ with early stage breast cancer for a trial investigating the Pre-Operative Window of adjuvant Endocrine therapy to inform Radiation therapy decisions (POWER)

• Cervical Cancer
• Patients with a locally advanced or metastatic solid tumor cancers are needed for a study to research an investigational immunotherapy
• A Randomized, Phase 3, Double-Blind Study of Chemoradiotherapy with or without immunotherapy for the Treatment of Stages IB2-IIB, III and IVA Cervical Cancer
• A Randomized Phase III Trial of Platinum-based Chemotherapy plus chemotherapy and antibody drugs with experimental immunotherapy versus standard-of-care Platinum-based Chemotherapy plus chemotherapy and anti-body drugs in Metastatic (stage IVB), Persistent, or Recurrent Cervical Cancer
• Research study for adults with gynecological cancer
• Patients with cervical cancer are needed for a study to research the disease will respond to an experimental drug vs. chemotherapy

• Colorectal Cancer
• Patients with metastatic colorectal cancers are needed for a study to research an experimental combination of 2 drugs
• Patients with a solid tumor cancer are needed for a study to research a combination of an experimental drug by itself or in combination with 2 FDA approved drugs.
• Patients with advanced colorectal cancers are needed for a study to research an experimental drug in comparison to chemotherapy

• Endometrial Cancer
• A Trial of Radiation Therapy for Adult Women with Early Stage Endometrial Cancer
• A Phase 3 Research Study for Women with Recurrent or Primary Advanced Endometrial Cancer
• Adults with Endometrial cancers invited to be in a research study

• Endometriosis
• Research Study for Women who have Complex Atypical Hyperplasia OR Stage 1a Grade 1 Endometrial Cancer

• Esophageal Cancer
• Adults with Locoregional Esophageal and Gastroesophageal Junction Adenocarcinoma invited to be in a research study

• Exercise Study
• Study for Patients Planning to Undergo Abdominal Surgery for Colorectal, Hepatobiliary, or Gynecologic Cancer

• Fallopian Tube Cancer
• Patients with advanced epithelial ovarian, fallopian tube, or peritoneal carcinoma cancers are needed for a study to research a chemo-immunotherapy.
• A Phase 1b/2a study for patients with platinum-resistant epithelial ovarian, fallopian tube or primary peritoneal cancer or those with advanced gynecological malignancies with a known ARID1A mutation

• Focused Ultrasound Surgery
• Adults with one or more metastatic tumors who have tried or are not eligible for other therapies are invited to be in a research study that uses focused ultrasound ablation therapy (AM003)
• Research study for those with high grade glioma

• Gliomas
• Research study for those with high grade glioma

• Head and Neck Cancer
• Patients with advanced head and neck squamous cell carcinoma cancer are needed for a study to research an experimental drug in combination with chemoradiation therapy
• Patients with advanced head and neck cancer are needed for a study to research the combination of an experimental drug and radiation therapy
• Advanced cancer patients who have had at least 1 chemotherapy treatment are needed for a research study.

• Healthy Subject Study
• Healthy Adults and Lung/Liver Cancer Patients are invited to be in a research study.

• Hormone Studies
• Research Study for Women who have Complex Atypical Hyperplasia OR Stage 1a Grade 1 Endometrial Cancer

• Kidney Cancer
• Patients with a solid tumor cancer are needed for a study to research a combination of an experimental drug by itself or in combination with 2 FDA approved drugs.
• Adults with kidney cancer invited to be in an immunotherapy research study
• Patients with advanced kidney cancer are being recruited for participation in a research study involving an experimental drug

• Leukemia
• Patients with recurrent or persistent acute myeloid leukemia (AML) or myelodysplastic syndrome (MDS) are needed for a study to research the combination of a chemotherapy and immunotherapy drug
• Adults over 60 years of age who will have an allogeneic stem cell transplant to treat their blood cancer are invited to be in a research study
• Study for Patients with Relapsed Acute Lymphoblastic Leukemia (ALL) Studying the Addition of Inotuzumab Ozogamicin to a Standard 3 and 4 Drug Standard Treatment for ALL
• Study for Patients with High Risk Leukemias or Myelodysplastic Syndrome to Start Supportive Care Earlier in the Treatment Regimen
• Study For Patients With Newly Diagnosed Acute Myeloid Leukemia To See If Drugs for Treating Heart Problems May Help To Prevent Heart Problems

• Liver Cancer
• Patients with a solid tumor cancer are needed for a study to research a combination of an experimental drug by itself or in combination with 2 FDA approved drugs.
• Patients with untreated, advanced biliary tract cancer are needed for a study to research the combination of chemotherapy and 2 investigational drugs
• Healthy Adults and Lung/Liver Cancer Patients are invited to be in a research study.

• Lung Cancer
• Research study for adults at risk, diagnosed with, or being evaluated for cancer
• Adults with lung, breast, or ovarian/fallopian tube cancers invited to be in a nerve disorder research study.
• Advanced cancer patients who have had at least 1 chemotherapy treatment are needed for a research study.
• Lung Cancer Surgical Trial
• Healthy Adults and Lung/Liver Cancer Patients are invited to be in a research study.
• Patients with nonsquamous non-small cell lung cancer are needed for a study to evaluate an experimental immunotherapy alone or in combination with chemotherapy
• Adults with endometrial cancer (EC), non-small cell lung cancer (NSCLC, adenocarcinoma), ovarian cancer, primary peritoneal cancer or fallopian tube cancer invited to be in a research study
• Radiation treatment research study for adults with non-small cell lung cancer
• A phase 1 study of entinostat in combination with atezolizumab, carboplatin, and etoposide in previously untreated extensive-stage small cell lung cancer
• A Randomized Phase 3 Study of MRTX849 (Adagrasib) Versus Docetaxel in Patients With Previously Treated Non-Small Cell Lung Cancer With KRAS G12C Mutation
• A phase 2 randomized open-label study of patritumab deruxtecan (U3-1402) in subjects with previously treated metastatic or locally advanced EGFR mutated non-small cell lung cancer (NSCLC) (HERTHENA-Lung01)

• Lymphomas
• Adults over 60 years of age who will have an allogeneic stem cell transplant to treat their blood cancer are invited to be in a research study
• Adults with Newly Diagnosed Mantle Cell Lymphoma invited to be in a research study comparing three chemotherapy regimens
• Patients with mantle cell lymphoma are needed for a research study on the effects of having an autotransplant
• Study for Patients with Peripheral T-Cell Lymphoma Comparing an Investigational Combination with Standard Treatment
• Study for Patients with Peripheral T-Cell Lymphoma (PTCL) or Cutaneous T-Cell Lymphoma (CTCL) Comparing an Investigational Combination of Pembrolizumab (Keytruda) with Decitabine and/or Pralatrexate (PTCL 002)

• Melanoma
• Patients with melanoma are needed for a study to research the combination of two immunotherapy drugs with and without the addition of protein injections
• A study of a combination of 2 immunotherapy drugs vs. 1 immunotherapy drug for patients at high risk for recurrence of melanoma
• Adults with advanced melanoma invited to be in a research study using biomarkers to help guide safe immunotherapy discontinuation
• Patients with Melanoma needed for a trial to evaluate outcomes of DecisionDx® test results when managed by observation or treated with adjuvant therapy
• Adults with stage IB – IV melanoma are invited to be in a research study testing a melanoma vaccine (Mel 66)

• meningioma
• Seeking Adults with Progressive Meningiomas

• Multiple Myeloma
• Study of Cell Transplantation in Medicare Multiple Myeloma Subjects

• Myelodysplastic Syndrome (MDS)
• Study for Patients with High Risk Leukemias or Myelodysplastic Syndrome to Start Supportive Care Earlier in the Treatment Regimen

• myelofibrosis
• Study of Oral TP-3654 in Patients with Myelofibrosis
• Database Study of Cell Transplant in Medicare Myelofibrosis Subjects

• Myeloma
• Adults over 60 years of age who will have an allogeneic stem cell transplant to treat their blood cancer are invited to be in a research study
• Adults with Smoldering Multiple Myeloma invited to be in a research study testing the addition of an immunotherapy drug to an immunomodulatory drug.
• Adults with Multiple Myeloma invited to be in a research study assessing the safety an investigational drug in combination with anti-myeloma regimens

• Oral Cancer
• Research to Study Quality of Life Following Robotic Surgery for Oral Cavity Cancer

• Ovarian Cancer
• Adults with lung, breast, or ovarian/fallopian tube cancers invited to be in a nerve disorder research study.
• Adults with endometrial cancer (EC), non-small cell lung cancer (NSCLC, adenocarcinoma), ovarian cancer, primary peritoneal cancer or fallopian tube cancer invited to be in a research study
• Women with Ovarian or Peritoneal Cancer Sought for Research Study.
• Patients with advanced epithelial ovarian, fallopian tube, or peritoneal carcinoma cancers are needed for a study to research a chemo-immunotherapy.
• Patients with recurrent ovarian, fallopian tube, or primary peritoneal cancer are needed for a study to research an immunotherapy drug
• A study testing the addition of VX-970 (inhibitor drug) to approved chemotherapy in Recurrent Platinum-Sensitive Ovarian Cancer, Peritoneal, and Fallopian Tube Cancer (Expansion Cohort)
• A randomized phase 2 study of immunotherapy drug, bevacizumab, in combination with either a weekly antibody drug conjugate, anetumab ravtansine, or weekly chemotherapy drug in platinum-resistant or platinum refractory ovarian, fallopian tube, or primary peritoneal cancer
• Adults with recurrent ovarian, fallopian tube or peritoneal cancers invited to be in a study testing an immunotherapy/PARP inhibition drug combination therapy.
• Patients with ovarian or peritoneal cancers are needed for a study to research a hormonal drug therapy
• A study to collect information and specimens from patients who will have surgery for a gynecologic condition to use in future research.
• A Phase 1/2 Research Study for Patients with Ovarian Clear Cell Carcinoma or Endometrial Carcinoma or other Advanced Solid Tumors
• A Phase 1b/2a study for patients with platinum-resistant epithelial ovarian, fallopian tube or primary peritoneal cancer or those with advanced gynecological malignancies with a known ARID1A mutation
• Advanced ovarian cancer patients who have had at least 1 chemotherapy treatment are needed for a research study.
• A Research Study for Adult Women with Recurrent High-grade serous, Endometrioid, or Clear Cell Ovarian, Fallopian Tube or Primary Peritoneal Cancer
• A Research Study for Adult Women with Platinum-Resistant Ovarian, Fallopian Tube or Primary Peritoneal Cancer
• A Phase 2 Research Study for Patients with Platinum-Resistant Ovarian Cancer
• Research Study for Adults with pancreatic adenocarcinoma, epithelial ovarian cancer, fallopian tube cancer, primary peritoneal cancer, and mesothelioma
• Research study for ovarian cancer patients with BRCA1 mutations to compare two surgical procedures
• Patients with recurrent platinum-resistant ovarian cancer are needed for a study to research the combination of abemaciclib and olaparib
• Women with low-grade serous ovarian cancer are needed for a study to evaluate an investigational drug alone or in combination with a 2nd investigational drug.
• Patients with advanced solid tumors are needed for a study to research the combination of an investigational drug and chemotherapy.

• Pancreatic Cancer
• Research Study for Adults with pancreatic adenocarcinoma, epithelial ovarian cancer, fallopian tube cancer, primary peritoneal cancer, and mesothelioma
• Patients with advanced pancreatic cancer are needed for a study to research an experimental cellular therapy.
• Patients with pancreatic cancer are needed for a study to research a combination of experimental immunotherapy, chemoradiation and surgery

• Pediatric Cancers: Brain Cancer
• Neuroblastoma Biology Studies: A Children's Oncology Group Study

• Pediatric Cancers: Neuroblastoma
• Neuroblastoma Biology Studies: A Children's Oncology Group Study

• Pediatric Cancers: Sarcomas
• A Group-Wide Protocol for Collecting and Banking Pediatric Cancer Research Specimens

• Peripheral T-Cell Lymphoma (PTCL)
• Study for Patients with Peripheral T-Cell Lymphoma Comparing an Investigational Combination with Standard Treatment

• Peritoneal Cancer
• Adults with endometrial cancer (EC), non-small cell lung cancer (NSCLC, adenocarcinoma), ovarian cancer, primary peritoneal cancer or fallopian tube cancer invited to be in a research study
• Women with Ovarian or Peritoneal Cancer Sought for Research Study.
• Patients with advanced epithelial ovarian, fallopian tube, or peritoneal carcinoma cancers are needed for a study to research a chemo-immunotherapy.
• Patients with recurrent ovarian, fallopian tube, or primary peritoneal cancer are needed for a study to research an immunotherapy drug
• A study testing the addition of VX-970 (inhibitor drug) to approved chemotherapy in Recurrent Platinum-Sensitive Ovarian Cancer, Peritoneal, and Fallopian Tube Cancer (Expansion Cohort)
• A randomized phase 2 study of immunotherapy drug, bevacizumab, in combination with either a weekly antibody drug conjugate, anetumab ravtansine, or weekly chemotherapy drug in platinum-resistant or platinum refractory ovarian, fallopian tube, or primary peritoneal cancer
• Adults with recurrent ovarian, fallopian tube or peritoneal cancers invited to be in a study testing an immunotherapy/PARP inhibition drug combination therapy.
• Patients with ovarian or peritoneal cancers are needed for a study to research a hormonal drug therapy
• A study to collect information and specimens from patients who will have surgery for a gynecologic condition to use in future research.
• A Phase 1b/2a study for patients with platinum-resistant epithelial ovarian, fallopian tube or primary peritoneal cancer or those with advanced gynecological malignancies with a known ARID1A mutation
• A Research Study for Adult Women with Recurrent High-grade serous, Endometrioid, or Clear Cell Ovarian, Fallopian Tube or Primary Peritoneal Cancer
• A Research Study for Adult Women with Platinum-Resistant Ovarian, Fallopian Tube or Primary Peritoneal Cancer
• Research Study for Adults with pancreatic adenocarcinoma, epithelial ovarian cancer, fallopian tube cancer, primary peritoneal cancer, and mesothelioma

• Primary Central Nervous System Lymphoma (PCNSL)
• Study for Adults with Primary Central Nervous System Lymphoma (PCNSL)

• Prostate
• Research study for adults with Prostate cancer

• Prostate Cancer
• Research study for adults at risk, diagnosed with, or being evaluated for cancer
• A study of an experimental drug in patients with metastatic castration resistant prostate cancer
• Advanced Prostate cancer patients who have had at least 1 curative-intent treatment are needed for a diagnosis research study.
• Newly Diagnosed Prostate cancer patients are needed for a diagnostic imaging research study
• Adults with metastatic prostate cancer invited to be in a combination chemotherapy/hormone therapy study
• Patients with prostate cancer are being recruited for participation in a research study involving Muscadine supplements
• Targeting Resistant prostate cancer with ATR and PARP inhibition (TRAP trial)
• Adults with castration-resistant prostate cancer invited to be in a research study
• Adults with metastatic castration-resistant prostate cancer invited to be in a research study
• Research study for adults with recurrent prostate cancer
• Radiation treatment research study for adults with prostate cancer
• Research study for adults with Prostate cancer
• Adults with Metastatic Castration Resistant Prostate Cancer invited to be in a research study assessing the safety and efficacy of an investigational drug

• Radiation Therapy
• Radiation treatment research study for adults with non-small cell lung cancer
• Research study for adults with recurrent prostate cancer
• Radiation treatment research study for adults with prostate cancer
• Research study for adults with Prostate cancer

• Rectal Cancer
• Research study for adults with Stage II or III Rectal Cancer.

• Skin Cancer
• Patients with Cutaneous Squamous Cell Carcinoma are needed for a study to research an immunotherapy drug
• Patients with advanced Cutaneous Squamous Cell Carcinoma and being treated with cemiplimab are needed for a research study

• Solid Tumors
• Adults with advance solid tumors invited to be in a research study testing an investigational drug.
• Adults with advanced and/or metastasized solid tumors who failed usual chemotherapy treatment are invited to be in a research study testing the immunotherapy drug

• Stem Cell Transplant
• Adults over 60 years of age who will have an allogeneic stem cell transplant to treat their blood cancer are invited to be in a research study
• Blood Sample Banking For Future Research
• Study of Cell Transplantation in Medicare Multiple Myeloma Subjects
• Database Study of Cell Transplant in Medicare Myelofibrosis Subjects
• Research Database on Transplants and Cellular Therapies

• Stomach Cancer
• Patients with advanced solid tumors are needed for a study to research the combination of an investigational drug and chemotherapy.

• Transplant
• Safety Study of Cell Transplant with Unlicensed Cord Blood (CB)

• Uterine Cancer
• Research study for adults with gynecological cancer
• A study to collect information and specimens from patients who will have surgery for a gynecologic condition to use in future research.
• Patients with advanced solid tumors are needed for a study to research the combination of an investigational drug and chemotherapy.
• Adults with Endometrial cancers invited to be in a research study
• Adults with endometrial cancer invited to be in a research study testing the addition of the immunotherapy drug to the usual chemotherapy treatment
• Adults with newly diagnosed high-risk endometrial cancer invited to be in a research study testing an immunotherapy drug.

• Vaginal/Vulval Cancer
• Research study for adults with gynecological cancer
• Women with Ovarian or Peritoneal Cancer Sought for Research Study.
• A study to collect information and specimens from patients who will have surgery for a gynecologic condition to use in future research.