Do you have dense breasts on mammography?

IRB/UVA Tracking #
20063
Principal Investigator
Harvey Jennifer, A
Contact First Name

Kathy

Contact Last Name

Repich

Contact Phone
Official Trial Title
A Randomized, Double-blind, Placebo Controlled Trial of
4-Hydroxytamoxifen Gel for Reducing Breast Tissue Density in Women with BI-RADS Breast Density Categories C or D
Study Description

The department of Radiology, Breast Imaging division seeks healthy women ages 35-75 with dense breasts on mammography for a research study. The purpose of the study is to determine if a topical gel containing a type of tamoxifen can reduce mammographic breast density.
You may not participate if you are pregnant or lactating, have prior history of cancer(excluding nonmelanoma skin cancer), have had a surgical breast biopsy in the last three years, a breast needle biopsy in the last year, have had prior reduction or augmentation breast surgery, have active liver disease or thromboembolic disorder, or are taking estrogen containing contraceptives or hormone replacement therapy (HRT).
In this study, women will apply the investigational gel containing a type of tamoxifen or a placebo gel to both breasts once per day for 52 weeks. We will analyze your breast density at an annual screening mammogram prior to participating in the study and again the following year at your annual screening mammogram
Study-related exams, tests and experimental medication are provided free of charge.
Participant’s insurance company will be billed for mammogram,

Compensation

$50 per study visit