Pulmonary/Respiratory Trials

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Xenon MRI and Advair in COPD

IRB/UVa Tracking #: 18667

Principal Investigator: Shim Yun, M

Contact: Rachel Dieterich

Tel: 4342436074

Email: rrd8w@virginia.edu

Study Description

The Radiology Research department seeks adults with chronic obstructive lung disease (COPD) or a history of smoking for a research study. The purpose of the study is to see whether hyperpolarized xenon-129 MRI can detect changes in the lungs after treatment with Advair, an FDA-approved treatment for COPD. The study involves inhaled hyperpolarized xenon MRI, perfusion MRI, spirometry, 6-minute-walk test, electrocardiogram (ECG), physical exam, chest CT, blood draw, and completion of questionnaires. The study requires one to three study visits over a three-month period, each lasting approximately two to three hours. Study-related drugs and tests including pulmonary function tests, chest CT, physical exam, ECG, perfusion MRI with gadolinium, and xenon MRI (insert exams, tests and experimental medication) provided free of charge