Obese Adults Needed for Exercise and Medication Study

IRB/UVA Tracking #
19364
Contact First Name

Stephanie

Contact Last Name

Miller

Contact Email
Contact Phone
Official Trial Title
Exercise dose and metformin for vascular health in adults with metabolic syndrome
Study Description

The Department of Kinesiology is conducting a study to evaluate whether combining different intensities of exercise while taking a medication commonly used to improve blood sugar levels, is more effective than exercise alone to improve blood flow in individuals at risk for type 2 diabetes. We are seeking males and females between the ages 40-70 years old not participating in an exercise program. Participants will be screened for risk factors; eligible participants will have at least 3. Participation in this study will occur over approximately 18 weeks. You will randomly be assigned to one of 4 groups; (1) a group who takes the medication and exercises at a high intensity, (2) a group who takes the medication and exercises at a low intensity, (3) a group who take a placebo pill and exercises at high intensity, and (4) a group who takes a placebo pill and exercises at low intensity. The exercise training will occur 3 times/wk at the University of Virginia Memorial Gymnasium with a personal trainer and 2 times/wk at home for 16 weeks. Assessments include clinical labs related to diabetes and heart disease risk, body fat, muscle mass, cardiovascular fitness and metabolism.
Study-related tests and procedures will be provided free of charge.

Compensation

up to $1000