A Phase III Multi-center, Open-label, Sponsor-blinded, Randomized Study of AZD0901 Monotherapy Compared with Investigator’s Choice of Therapy in Second- or Later-Line Adult Participants with Advanced/Metastatic Gastric or Gastroesophageal Junction Adenocarcinoma Expressing Claudin18.2

The University of Virginia seeks participants ages 18 and over with advanced or metastatic gastric, gastroesophageal junction, or esophageal cancer. The purpose of this study is to learn more about the effectiveness and safety of the investigational study drug AZD0901 compared to a standard therapy that will be selected by your study doctor per your disease status.

In this study, you will undergo a screening period that can last up to 28 days. During the screening period, the doctor will run various tests to make sure you are eligible for the study. You will give a sample of your tumor to determine if your cancer cells show CLDN18.2. Your cancer cells must show ClDN18.2 in order to participate with the study. If you meet the screening criteria you will be randomly assigned to a study treatment. Your visit schedule will be based on what treatment you are receiving. You will have more exams, tests, and procedures to closely monitor your safety and health. Your participation with the study depends on how you respond to the drug, your participation may be shorter or longer. If you respond to the treatment you will continue on therapy as long as you benefit from it.

Study-related procedures that are being done beyond your standard of care will be provided at no cost to you or your insurance.

Additional information can be found here: https://clinicaltrials.gov/study/NCT06346392

uvacancertrials@hscmail.mcc.virginia.edu

The (department, division name) seeks (insert as applies: adults/men/women/adolescents/children) ages (insert) with (insert condition) for a research study. The purpose of the study is (insert purpose of study - eg.to test the effectiveness of an investigational medicine; or to find out how stress effects blood pressure.)

(Optional)You may be eligible for this study if: (insert brief eligibility criteria 3 or 4 top criteria and in lay language. Do not copy eligibility criteria from the protocol)

Study involves (insert procedures-examples: taking an experimental medicine/placebo, blood draws, x rays, overnight stays,) (Insert x number of visits every x (weeks, months,) each visit lasting x amount of time or give range).

Insert one of the following:
Study-related (insert exams, tests and experimental medication) provided at no cost.
or
Participant’s insurance company will be billed for medication, tests and procedures