Seeking adults with Parkinson’s disease experiencing “OFF” episodes

IRB/UVA Tracking #
19188
Contact First Name

Katie

Contact Last Name

Sullivan

Contact Email
Contact Phone
Official Trial Title
An Open-Label, Phase 3 Study Examining the Long-Term Safety, Tolerability and Efficacy of APL-130277 in Levodopa Responsive Patients with Parkinson’s Disease Complicated by Motor Fluctuations (“OFF” Episodes)(CTH-301)
Study Description

The UVA Parkinson’s Disease and Movement Disorder Center is conducting a research study to evaluate the safety and effectiveness of an investigational drug used to quickly resolve episodes when Parkinson’s medication is not working as it should, usually described as “OFF” episodes.
Participation includes approximately 13 study visits, including the screening and follow up visits, and an at-home study treatment period. Participants will be evaluated in the neurology clinic to determine the right starting dose for treating your “OFF” episodes. Once your correct dose has been identified, you will receive a supply of the study drug to self-administer at home for up to 5 “OFF” episodes per day, as needed, for 24 weeks. You will return to the clinic at regular intervals for follow-up. The total length of study participation will be about 231 days.
Study-related exams, tests and experimental medication provided free of charge. Reimbursement for any travel or lodging required to complete the study is also available.

Ages: Adults age 18 or older.

Compensation

Up to $800