M. Yashar S. Kalani

M. Yashar S. Kalani, MD, PhD

General Neurological Surgery Appointment
Neurological Surgery
Call 434.924.2735
Primary Location:
Adult Neurology Clinic

Fourth Floor

1221 Lee St.

Charlottesville, VA 22903

ABMS Certification:
Neurological Surgery
Research Interests:

Central Nervous System Development and Regeneration, Central Nervous System Tumors, Extracellular RNAs (ex-RNAs) as Signaling Molecules and Biomarkers in Development and Disease, Stem Cell Biology, Vascular Development, Central Nervous System Vascular Malformations, Cerebral Aneurysms, Stroke

Clinical Practice:
Arteriovenous Malformations (AVMs), Carotid Artery Disease, Cerebral (Brain or Intracranial) Aneurysm, Cushing's Disease, Glioblastoma Multiforme (GBM), Meningioma, Pituitary Adenomas, Spinal Tumors, Subarachnoid Hemorrhage, Transient Ischemic Attack (TIA) (Mini-stroke), Trigeminal Neuralgia, Brain Tumors, Carotid Endarterectomy, Craniopharyngioma, Ischemic Stroke, Petrous Apex Lesions, Pseudotumor Cerebri, Vascular Malformations, Aneurysms, Artery Disease, Microvascular Clipping, Neurovascular Surgery, Carotid Artery Stenosis, Endovascular Embolization, Hereditary Hemorrhagic Telangiectasia (HHT), Brain Metastases, Neuroradiology, Stroke, Skull Base Conditions, Optic Nerve Gliomas, Cavernoma
Associate Professor

Yashar Kalani, MD, PhD, FAANS, FAHA, is an internationally recognized expert in skull base and cerebrovascular neurosurgery. Board-certified by the American Board of Neurological Surgery, he is fellowship-trained in cerebrovascular, skull base and endovascular surgery.

As a neurosurgeon dual-trained in both open and endovascular techniques, he is uniquely qualified to consult on patients with cerebrovascular disease, offer an unbiased opinion between open and minimally invasive surgeries and provide the safest and most effective treatment options available. His expertise in keyhole surgery, neuroendoscopy and classic skull base approaches allows him to provide unique treatment options to patients with conditions that affect deep-seated regions of the brain, brainstem and spinal cord.

Originally from southern California, Kalani obtained a combined Bachelor of Science and Master of Science in chemistry and biochemistry from the University of California, Los Angeles. He subsequently completed a second Master of Science and received his PhD in chemistry from the California Institute of Technology. Kalani earned his medical degree from Stanford University School of Medicine, where he also completed postdoctoral studies in Stem Cell Biology and Regenerative Medicine; he was supported by fellowships from the Howard Hughes Medical Institute, the American Medical Association, the American Heart Association and the Soros Foundation. Kalani completed his clinical training at the Barrow Neurological Institute, and was a Murdock fellow at the Center for Minimally Invasive Neurosurgery in Sydney.

As director of a National Institutes of Health-funded laboratory, Kalani studies the role of extracellular RNAs (a type of nucleic acid) as markers for injury in the central nervous system. His laboratory also investigates the interaction between endothelial cells and central nervous system progenitors or cells during development and in the setting of disease. He is investigating the role of mitochondrial transplantation as a neuroprotective strategy after ischemic stroke.

Kalani’s clinical interests focus on the comprehensive management of cerebral and spinal aneurysms, vascular malformations and tumors. He has a particular interest in cerebral revascularization (including for Moyamoya disease) and surgery of deep-seated lesions within the thalamus, brainstem and the spinal cord.

Kalani has published more than 200 peer-reviewed articles and 50 book chapters in neuroscience literature. He has co-edited a number of neurosurgical textbooks, including “Neurovascular Surgery, Comprehensive Management of Arteriovenous Malformations of the Brain and Spine,” “The Color Atlas of Brainstem Surgery,” and “Surgery of the Brainstem.”

Currently, Kalani serves as vice chair of research, the surgical director of the University of Virginia Comprehensive Stroke Center, co-director of cerebrovascular and endovascular surgery, and director of skull base surgery.


2018                      Prose Award for Textbook/Clinical Medicine for Color Atlas of Brainstem Surgery

2016-2017             University of Utah School of Medicine, inaugural EDGE Scholar

2016-2017             University of Utah Vice President’s Clinical and Translational Scholars Program

2016                      Silver Winner of the IBPA Benjamin Franklin Award for Neurovascular Surgery textbook

2014                      Sir Keith Murdoch Fellowship from the American Australian Association

2015                      John R. Green Award, Original Research, Arizona Neurosurgical Society

2011                      American Medical Association Seed Grant Recipient in Cardiovascular Medicine

2011                      John R. Green Award, Original Research, Arizona Neurosurgical Society

2009                      John R. Green Award, Original Research, Arizona Neurosurgical Society

2008-2009             John and Shirley Hanbery Scholar

2005-2009             Howard Hughes Medical Institute Fellow

2006-2008             Paul and Daisy Soros Fellow

2007                      Academy of Achievement, Student Member

2006                      American Medical Association Seed Grant Recipient in Neoplastic Diseases


Stanford University
Barrow Neurological Institute
Barrow Neurological Institute