M. Yashar S.  Kalani

M. Yashar S. Kalani, MD, PhD

General Neurological Surgery Appointment
Neurological Surgery
Call 434.924.2735
Primary Location:

PO Box 800212

Charlottesville, VA 22908

Secondary Locations:
Research Interests:

Central Nervous System Development and Regeneration, Central Nervous System Tumors, Extracellular RNAs (ex-RNAs) as Signaling Molecules and Biomarkers in Development and Disease, Stem Cell Biology, Vascular Development, Central Nervous System Vascular Malformations, Cerebral Aneurysms, Stroke

Clinical Practice:
Arteriovenous Malformations (AVMs), Carotid Artery Disease, Cerebral (Brain or Intracranial) Aneurysm, Cushing's Disease, Glioblastoma Multiforme (GBM), Meningioma, Pituitary Adenomas, Spinal Tumors, Subarachnoid Hemorrhage, Transient Ischemic Attack (TIA) (Mini-stroke), Trigeminal Neuralgia, Brain Tumors, Carotid Endarterectomy, Craniopharyngioma, Ischemic Stroke, Petrous Apex Lesions, Pseudotumor Cerebri, Vascular Malformations, Aneurysms, Artery Disease, Microvascular Clipping, Neurovascular Surgery, Carotid Artery Stenosis, Endovascular Embolization, Hereditary Hemorrhagic Telangiectasia (HHT), Brain Metastases, Neuroradiology, Stroke, Skull Base Conditions, Optic Nerve Gliomas, Cavernoma
Associate Professor

Yashar Kalani, MD, PhD joined the faculty of the Departments of Neurological Surgery, Neurology and Neuroscience at UVA in 2017. Dr. Kalani is fellowship trained in cerebrovascular, skull base and endovascular surgery. As a neurosurgeon dual-trained in both open and endovascular techniques, he is uniquely qualified to consult on patients with cerebrovascular disease, offer an unbiased opinion between open and minimally-invasive surgeries and provide the safest and most effective treatment options. His expertise in both neuroendoscopy and classic skull base approaches similarly allows him to provide unique options to patients with pathology in deep-seated regions of the brain, brainstem and spinal cord.

Dr. Kalani was raised in southern California. He obtained a combined B.S./M.S. in Chemistry and Biochemistry from the University of California, Los Angeles in 2002 with college, Latin and University honors. He next completed a second M.S. and Ph.D. in Chemistry from the California Institute of Technology in 2004, and went on to complete his M.D. and postdoctoral studies at Stanford University School of Medicine where he was supported by fellowships from the Howard Hughes Medical Institute, the American Medical Association, the American Heart Association and the Soros Foundation. In 2009, he began his clinical training at the Barrow Neurological Institute where he completed fellowship training in complex spine, cerebrovascular and skull base surgery and endovascular neurosurgery. He was a Murdock fellow of the American Australian Association and completed further fellowship in neuroendoscopy and minimally invasive neurosurgery in Sydney.

Dr. Kalani directs an NIH-funded laboratory where he studies the role of extracellular RNAs as markers for injury to the central nervous system. His laboratory also investigates the interaction between endothelial cells and central nervous system progenitors during development and in the setting of disease. He is actively investigating the role of small molecules as inhibitors of cerebral cavernous malformation growth and development.

Dr. Kalani’s clinical interest focus on the comprehensive management of cerebral and spinal aneurysms, vascular malformations and tumors. He has a particular interest in cerebral revascularization (including for Moyamoya disease), and surgery of deep-seated lesions within the thalamus, brainstem and the spinal cord.

Dr. Kalani has published more than 150 articles and 40 book chapters in the neuroscience literature. He has co-edited a number of neurosurgical textbooks, including Neurovascular Surgery, Comprehensive Management of Arteriovenous Malformations of the Brain and Spine, and the Color Atlas of Brainstem Surgery.

Currently, Dr. Kalani serves as co-director of cerebrovascular and endovascular surgery and director of skull base surgery.


2018                      Prose Award for Textbook/Clinical Medicine for Color Atlas of Brainstem Surgery

2016-2017             University of Utah School of Medicine, inaugural EDGE Scholar

2016-2017             University of Utah Vice President’s Clinical and Translational Scholars Program

2016                      Silver Winner of the IBPA Benjamin Franklin Award for Neurovascular Surgery textbook

2014                      Sir Keith Murdoch Fellowship from the American Australian Association

2015                      John R. Green Award, Original Research, Arizona Neurosurgical Society

2011                      American Medical Association Seed Grant Recipient in Cardiovascular Medicine

2011                      John R. Green Award, Original Research, Arizona Neurosurgical Society

2009                      John R. Green Award, Original Research, Arizona Neurosurgical Society

2008-2009             John and Shirley Hanbery Scholar

2005-2009             Howard Hughes Medical Institute Fellow

2006-2008             Paul and Daisy Soros Fellow

2007                      Academy of Achievement, Student Member

2006                      American Medical Association Seed Grant Recipient in Neoplastic Diseases


Stanford University
Barrow Neurological Institute
Barrow Neurological Institute