ORIEN: Clinical Research Services

Questions?

Through the biobanking efforts of the ORIEN team and UVA's Biorepository and Tissue Research Facility (BTRF), our investigators will have access to these services:

Study Management

  • Pre-screening of potential study participants
  • Compliant consent of study participants
  • Survey administration and phone follow-up
  • Specimen coordination, processing and shipping
  • Chart review/case report form completion

Clinical Data Services

  • Data abstractions from EPIC to complete case report forms
  • Coordinate upload of EPIC data extractions into REDCap or other data capture systems
  • Queries on internal and external ORIEN databases for project feasibility
  • Coordinate with Research and Clinical Trial Analytics Team and Cancer Registry for project data needs
    • Feasibility for grant applications
    • Feasibility for clinical trials for actual number of qualifying patients

Molecular Data Access With Clinical Data

  • Access to whole exome sequencing and RNA sequencing for tumor and whole exome sequencing for germline samples
    • Project-specific access to raw molecular files for UVA consented patients
    • Query processed data using ORIEN informatics modules and ORIEN CBioPortal
  • Project submissions for access to molecular data from other ORIEN sites

Specimen Management

Studies may either rely on the specimen management that is part of the ORIEN protocol through the ORIEN core functions or may rely on an independent protocol with consent with unique specimen criteria. For those studies that rely on the ORIEN protocol, the following table provides the collection details.

Specimens

Tube Type

Collection Volume

Collection Limit

Products

Comments

Blood from solid tumor patient

K2EDTA

10 mL

Cumulative blood collection total of 60 mL/8wk

1 mL whole blood stored for future germline sequencing, remainder stored as buffy coat and 1 mL plasma aliquots

Modification to usual collection or processing generate additional charges

Blood from blood cancer patient

Na heparin

20 mL

Cumulative blood collection total of 60 mL/8wk

Viably frozen mononuclear cell aliquots

Modification to usual collection or processing generate additional charges

Blood from blood cancer patient: For Circulating tumor DNA

Streck tube

10 mL

Cumulative blood collection total of 60 mL/8wk Determined on project specific basis

Project specific basis and fees apply

Bone marrow aspirates

Sodium heparin

10 mL

10 mL/4wk

Viably frozen mononuclear cell aliquots

 

Buccal swabs

MAWI DNA kit

1 swab kit

2 per year

Cell suspension

 

Lymph Node FNA

Extra pass (blood cancers only)

   

2 extra passes

Snap frozen for cores, RPMI for FNA