The UVA Cancer Center has approximately 220 full and associate members divided into five research programs. Each of these programs represents an area of expertise important for understanding how cancer starts and progresses and for development of interventions to detect, diagnose, treat, and prevent cancer. Each program has a natural affinity and identity, with sub-groups that make sense scientifically. In addition, each of these programs has helped generate major discoveries important for cancer:
- The Cancer Biology Program supports research focused on identification and validation of targets, development of small molecule modulators of validated targets, and elucidating mechanisms, particularly signaling networks, driving cancer.
- The Cancer Control and Population Health Program conducts population-based research to identify cancer risk, reduce cancer risk and develop systems to support cancer survivors.
- The Cancer Therapeutics Program supports preclinical science and validation of therapeutic targets leading to investigator-initiated clinical trials for cancer diagnosis, imaging, therapy or survivorship.
- The Molecular Genetics and Epigenetics Program was the origin of the discovery of the "histone code" and is nationally regarded as a premiere program for the study of chromatin and epigenomics.
- The Unaligned Research Program includes members of the Cancer Center research program who provide key contributions, but their work is not easily aligned with any of the core programs listed above.