Research Programs

The UVA Cancer Center has approximately 220 full and associate members divided into five Research Programs. Each of these programs represents an area of expertise important for understanding how cancer starts and progresses and for development of interventions to detect, diagnose, treat, and prevent cancer. Each program has a natural affinity and identity, with sub-groups that make sense scientifically. In addition, each of these programs has helped generate major discoveries important for cancer:

  • The Cancer Cell Signaling Program supported research that led to the discovery of MAP Kinase and FAK, and is supporting the application of cell signaling expertise to drug discovery.
  • The Chemical and Structural Biology Program has solved the structures of several proteins of key importance for cancer, including Rho-GDI and RUNX proteins, and is using this information for drug discovery and development.
  • The Immunology/Immunotherapy Program has been our most successful at translation to the clinic, and provides the scientific underpinnings for our track record in cancer vaccines.
  • The Molecular Genetics and Epigenetics Program was the origin of the discovery of the "histone code" and is nationally regarded as a premiere program for the study of chromatin and epigenomics.
  • The Women's Oncology Program investigators are involved in identifying molecular indicators of response in novel therapies in breast and gynecological cancers.
  • The Cancer Control and Population Health Program conducts population-based research to identify cancer risk, reduce cancer risk, and to develop systems to support cancer survivors.
  • The Unaligned Research Program includes members of the cancer center research program who provide key contributions, but their work is not easily aligned with any of the core programs listed above.