Chemical and Structural Biology Research Program

Detailed understanding of molecular function in biological systems requires information about the three-dimensional structures of macromolecules. The wealth of information available from studies in structural biology provides novel and powerful insights into function. Chemical biology, the modulation of protein function by small molecules, provides both tool compounds to explore biological function as well as leads for development of therapeutic agents. The merging of the structural and chemical biology faculties brings together two groups that speak the same language, the language of molecular structure, making the merger a natural grouping.

The Chemical and Structural Biology Program (CSB) defines its overarching goal as the facilitation of this dialogue to accelerate understanding and treatment of cancer. CSB focuses this goal around three thematic elements:

  • Structural and chemical biology targeting transcription factors
  • Structural and chemical biology targeting signaling molecules
  • Chemical biology for imaging, detection, and diagnosis

John H. Bushweller, PhD, Professor of Molecular Physiology and Biological Physics, leads the Program with Kevin R. Lynch, PhD Professor of Pharmacology and of Biochemistry and Molecular Genetics. By including members from the Chemistry Department, the Program provides unique, cross-campus opportunities to bring the power of chemistry to bear on cancer.

See more information about program members and their research interests.