Molecular Genetics and Epigenetics Program (GEN) Members

Tarek Abbas MD, PhD
Assistant Professor, Radiation Oncology
The ubiquitin system and human cancer; the regulated process of protein ubiquitination and proteolysis of DNA sensing and repair molecules.

Roger Abounader, MD, PhD
Professor, Microbiology, Immunology, and Cancer Biology
Roles and targeting of c-Met in brain tumors; c-Met/PTEN interactions in gliomas; PTEN/mutant-p53 interactions in gliomas; microRNAs in brain tumors.

David Auble, PhD
Professor, Biochemistry and Molecular Genetics
Chromatin remodeling during sensing and repair of DNA damage.

Stefan Bekiranov, PhD
Associate Professor, Biochemistry and Molecular Genetics
Developing algorithms for analysis of sequence data to extract insight into chromatin and epigenetic regulation. Applying quantum computers to bioinformatic analysis.

Sanchita Bhatnagar, PhD
Assistant Professor, Biochemistry and Molecular Genetics
Epigenetic silencing mechanisms: implications in breast cancer.

Francine Garrett-Bakelman, MD, PhD
Assistant Professor, Hematology and Oncology
Epigenetic changes underlying Acute Myeloid Leukemia.

Michael Guertin, PhD
Assistant Professor, Biochemistry and Molecular Genetics
Transcriptional changes underlying tumorigenesis.

Marie-Louise Hammarskjold, MD, PhD
Professor, Microbiology, Immunology, and Cancer Biology
Regulation by RNA and Retrovirology and export of RNAs in HIV-infected cells; relevance to HIV-associated neoplasms.

Hao Jiang, PhD
Associate Professor, Biochemistry and Molecular Genetics
Changes to splicing and biomolecular condensates that underlie cancer.

James Larner, MD
Professor, Radiation Oncology
Molecular basis of resistance to radiation; development of techniques for target-tissue sensitization to ionizing radiation; development of therapeutic focused ultrasound.

Hui Li, PhD
Associate Professor, Pathology
Trans-splicing as a novel regulatory mechanism in cancer.

Marty Mayo, PhD
Professor, Biochemistry and Molecular Genetics
NFkB involvement in the suppression of apoptosis in non-small-cell lung cancer and in the epithelial-mesenchymal transition.

Bryce Paschal, PhD
Professor, Biochemistry and Molecular Genetics
Androgen signaling and ADP-ribosylation in prostate cancer.

William Pearson, PhD
Professor, Biochemistry and Molecular Genetics
Identification of protein homologs and mechanisms to measure aneuploidy in tumors by developing novel computational algorithms.

Aakrosh Ratan, PhD
Assistant Professor, Public Health Sciences
Genomics, Molecular Evolution, Algorithm Design and Analysis.

David Rekosh, PhD
Professor, Microbiology, Immunology, and Cancer Biology
RNA based regulatory mechanisms.

Nathan Sheffield, PhD
Assistant Professor, Public Health Sciences
Computational methods to identify drivers of AML.

Jeffrey Smith, PhD
Professor, Biochemistry and Molecular Genetics
Role of the NADH-dependent deacetylase, sirtuin, in modulating gene expression in aging and carcinogenesis.

P. Todd Stukenberg, PhD
Professor, Biochemistry and Molecular Genetics
Role of Aurora kinases in mitosis and how their disfunction drives aneuploidy in tumorigenesis.

Yuh-Hwa Wang, PhD
Professor, Biochemistry and Molecular Genetics
Roles of Fragile Site breakage in generating translocations in tumors.

Chongzhi Zang, PhD
Assistant Professor, Public Health Sciences
Development of bioinformatic algorithms to apply the vast amounts of publicly available RNA seq data to cancer problems.

Hui Zong, PhD
Associate Professor, Microbiology, Immunology, and Cancer Biology
MADM, a mouse genetic mosaic model, to study how tumor cells originate and compete.