Clinical Trials & Research
We are dedicated to cutting-edge research that advances the field of transplant. Our mission is to advance patient care and the standard for clinical excellence by becoming a leader in innovative research discoveries and collaborations.
You can be part of the crucial research that saves lives. Learn about the benefits of joining a clinical trial.
The Genomics Transplant Translational Laboratory aims to improve outcomes and quality of life for patients. It has developed ways to provide earlier diagnoses for liver, kidney and pancreas transplant patients, beneficial for earlier and more successful treatments.
Pancreatic Cell & Artificial Pancreas Research
The Cellular Therapeutics and Transplantation Lab works to discover strategies that can predict and prevent the onset of autoimmune Type 1 diabetes, reverse β-cell destruction and permanently restore glycometabolic control.
- The GMP Cell Processing Core takes healthy islets from a patient's poorly functioning pancreas, purifies them and infuses them back into the patient. It is also exploring biocompatible materials that can be printed with 3D technology and used to create an artificial pancreas.
- The Induced Pluripotent Stem Cell Core is working on technology that can create the pancreatic cells from a patient’s own tissues, such as skin cells.
Lung Transplant Research
Our lung transplant team studies clinically relevant issues on post-transplant lung injury and rejection.
Current research projects include:
- T cells & IL-17 — role of T cells in lung ischemia-reperfusion injury
- Dendritic cells & IL-23/12 — role of dendritic cells in lung ischemia-reperfusion injury
- Adenosine receptors — role of adenosine receptors in lung ischemia-reperfusion injury
- RAGE/HMGB1 axis — role of RAGE signaling in lung injury
- NADPH oxidase — lung ischemia-reperfusion injury
- Pig lung transplant — protection from post-transplant lung injury
- EX Vivo Lung Perfusion (EVLP) — rehabilitate donor lungs for transplant
- Human EVLP — rehabilitation of marginal human donor lungs
- Transplantation immunology — molecular and cellular mechanisms of lung injury relevant to lung transplantation
- Stem cell therapy — reduce lung injury after transplant
What if we could grow organs instead of having to find donors when someone needs a transplant?
It may seem like something from science fiction, but researchers at the UVA School of Medicine have indeed created a framework for future studies looking at growing tissues and organs from cells.
Read more about this organ-growing research.