Gregory R Madden

Gregory R Madden, MD

Infectious Diseases and International Health
Primary Location:
Infectious Diseases Clinic

5th Floor, Outpatient Clinic

1300 Jefferson Park Ave.

Charlottesville, VA 22903



ABMS Certification:
Internal Medicine
Research Interests:

Dr. Madden is a physician scientist interested in translating advances in basic science and computer modeling to optimize the diagnosis and prevention of healthcare-associated infections.


Assistant Professor

As an academic infectious diseases specialist, Madden is part clinician and part scientist. His clinical duties include working in the office of hospital epidemiology with efforts related to COVID-19 and infection control and prevention. He was one of the early volunteers to assist with community coronavirus testing in Charlottesville. 

Madden also sees patients in the UVA Infectious Diseases Clinic for a broad range of infectious conditions, from osteomyelitis and bloodstream infections to tick-borne infections. A former academic hospitalist, he has a particular interest in hospital medicine. He regularly takes on the role of attending physician for general internal medicine, training medical house staff, in addition to working with infectious disease fellows. 

Madden’s research interests include enhancing the diagnosis and prevention of healthcare-associated infections, particularly C. difficile. His work straddles two realms: the host immunology and hospital epidemiology. For example, during his fellowship, he worked with the UVA Office of Hospital Epidemiology to develop a successful computerized algorithm that improved C. difficile diagnostics. At the same time, he worked with the UVA Department of Microbiology, Immunology, and Cancer biology to identify immune biomarkers to predict which patients with C. difficile are at the highest risk of dying from their infection. 

He hopes to harness immune biomarkers and other basic science insights to enhance clinical diagnostics in a way that allows clinicians and hospital epidemiologists to better care for patients and stop the spread of healthcare pathogens. Related projects include working with colleagues throughout UVA to quantify the cost of C. difficile overdiagnosis, improve infection control practices at a hospital in Rwanda, and develop a model of healthcare pathogen spread. 

Born and raised near Annapolis, Maryland, Madden completed his undergraduate degree at the University of Delaware before attending medical school at UVA, where he graduated with honors. He did his internal medicine residency at Yale University in New Haven, Connecticut. He then spent two years as an academic hospitalist at Beth-Isreal Deaconess Medical Center in Boston, Massachusetts. Madden then returned to UVA to complete his infectious diseases fellowship.

Madden is married to UVA Developmental Pediatrics Nurse Practitioner Dana Madden. The couple has toddler twins, a boy, and a girl. In his free time, Madden enjoys fly fishing.


UVA School of Medicine
Yale University School of Medicine
University of Virginia