Mark E. Shaffrey

Mark E. Shaffrey, MD

General Neurological Surgery Appointment, Neurosurgery, Spine
Neurological Surgery
Primary Location:
Spine Care Fontaine

3rd Floor

415 Ray C. Hunt Drive

Charlottesville, VA 22903

Secondary Locations:


ABMS Certification:
Neurosurgery, 2000
Research Interests:

Novel brain tumor treatments, Brain tumor outcome research, Clinical trials

Clinical Practice:
Astrocytoma, Neck Fracture, Vertebral Compression Fracture, Cervical Myelopathy, Neck Sprains and Strains, Chronic Neck Pain, Degenerative Disc Disease, Glioblastoma Brain Tumor Treatment, Herniated Disc, Meningioma, Spinal Stenosis, Spinal Tumors, Spondylolysis, Brain Tumor Diagnosis, Esthesioneuroblastoma, Laminectomy, Spinal Fusion, Lumbar Stenosis, Cervical Disc Disease, Lumbar Disc Herniation, Cervical Disc Herniation, Cervical Stenosis, Degenerative Scoliosis, Degenerative Spondyloisthesis, Isthmic Spondylolisthesis, Lumbar Degenerative Disc Disease, Cervical Artificial Discs, Computer Enhanced Navigation: Image Guided Spine Surgery, Spinal Implants, ALIF, DLIF, PLIF, TLIF, Spondylolisthesis, Lumbar Radiculopathy, Spine, Skull Base Conditions, Lordosis Treatment, Artificial Discs, Brain Tumor Treatment, Benign Brain Tumor

Chair, Department of Neurosurgery



Mark Edwin Shaffrey, MD, is a professor of neurosurgery and chair of the Department of Neurosurgery at the University of Virginia. He has won numerous awards for laboratory investigation and clinical medicine, including a traveling fellowship from the Royal College of Surgeons, and has been named to the Best Doctors in America list.

Dr. Shaffrey graduated magna cum laude from Virginia Tech and received his medical degree from the University of Virginia, where he was elected to the Alpha Omega Alpha honor society. He completed his general surgical internship at Wilford Hall USAF Medical Center and his neurosurgical training at the University of Virginia in 1994. During residency, he completed a clinical neuropathology fellowship and an NIH postdoctoral fellowship in microvascular physiology. He also trained as a skull base surgery fellow in Ljubljana, Slovenia, and served as a neurosurgical registrar in Plymouth, England.  

Following his postgraduate training, Dr. Shaffrey served as chief of neurosurgery at Keesler USAF Medical Center, and was decorated with the Meritorious Service Medal. In 1997, he returned to the University of Virginia as an associate professor of neurosurgery and founded the Neuro-Oncology Center. He was appointed chair of the Department of Neurosurgery in 2006.

Dr. Shaffrey’s research interests in neuro-oncology include the molecular mechanisms of cellular invasion and migration. He has approximately 100 publications and has been a funded principal investigator in over 40 grants and clinical trials. He serves on the editorial board and as topic editor for the Self-Assessment in Neurological Surgery (SANS). He is also a reviewer for the Journal of Neurosurgery, Neurosurgery, Surgical Neurology, and Cancer.  

In addition, Dr. Shaffrey plays an active role in organized neurosurgery, having served in several roles for the Congress of Neurological Surgeons and the American Association of Neurological Surgeons.

  • 2019 Best Bedside Manner Awards, OurHealth Charlottesville and Shenandoah Valley Magazine; First Place, Surgery – Neurosurgery
  • 2018 Best Bedside Manner Awards, OurHealth Charlottesville and Shenandoah Valley Magazine; First Place, Surgery: Neurosurgery
  • 2015 One of America's Top Cancer Doctors, Newsweek®
  • 2011-2020 Best Doctors in America® List


University of Virginia, 1987
Neurosurgery, University of Virginia
Neuropathology and Microvascular, University of Virginia