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Mark E. Shaffrey, MD

Department: Neurological Surgery Division: General Neurological Surgery Appointment Title: Professor and Chair of Neurosurgery ABMS Certification: Neurosurgery, 2000 Other Appointment: Chair, Department of Neurosurgery

Contact Information

P.O. Box 800212 Charlottesville, VA 22908-0212 Phone: 434.924.1843 Other Locations:
Spine Center
Neuro Oncology Center


Mark Edwin Shaffrey was born in Upper Darby Pennsylvania. He graduated magna cum laude from Virginia Tech in 1983 with B.S. degrees in Biochemistry and Biology. In 1987, Dr. Shaffrey received his medical degree from the University of Virginia, following election to Alpha Omega Alpha. He completed his general surgical internship at Wilford Hall USAF Medical Center in 1988 and his neurosurgical training under Dr. John Jane at the University of Virginia in 1994. During residency, he completed an NIH postdoctoral fellowship in microvascular physiology in the laboratory of Dr. Claude Desjardins and a clinical neuropathology fellowship with Dr. Scott VandenBerg. He trained with Dr. Vinko Dolenc as a skull base surgery fellow in Ljubljana, Slovenia and served as a neurosurgical registrar in Plymouth, England.  

Following his postgraduate training, Dr. Shaffrey completed a scholarship obligation to the United States Air Force where he served as the Chief of Neurosurgery at Keesler USAF Medical Center in 1997. He was decorated with the Meritorious Service Medal. In 1997, he returned to the University of Virginia as Associate Professor, Vice-Chairman and Co-Program Director of the Department of Neurosurgery and founded the Neuro-Oncology Center. In 2003, he was promoted to Professor of Neurosurgery. In 2006, he was appointed Chairman of the Department of Neurosurgery at the University of Virginia. Dr. Shaffrey has an active research interest in neuro-oncology, particularly in the molecular mechanisms of cellular invasion and migration. He has approximately 100 publications. He has been a funded principal investigator in over 40 grants and clinical trials. He serves on the Editorial Board and Topic Editor for the Self-Assessment in Neurological Surgery (SANS). He is an active reviewer for the Journal of Neurosurgery, Neurosurgery, Surgical Neurology, and Cancer.  

During his career in medicine, Dr. Shaffrey has won numerous awards for laboratory investigation and clinical medicine. In 1999, he was awarded a Traveling Fellowship by the Royal College of Surgeons. He has been named to Best Doctors and Best Doctors in America (Cancer). He has an active role in organized neurosurgery. For the Congress of Neurological Surgeons, he has served as an appointee to the CSNS, on the Scientific Program Committee, and the Practical Courses Chair. He currently chairs the Member Benefit Development Committee for the American Association of Neurological Surgeons.

Learn more about Dr. Mark Shaffrey (video).


  • 2016, 2015, 2014, 2013, 2012, 2011 Best Doctors in America® List
  • 2015 One of America's Top Cancer Doctors, Newsweek®


View all publications on PubMed