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Liver Disease Treatment

caregiver and patient

Liver disease can threaten your life. The liver cleans your blood and fights infections. It helps you digest food and store energy. An unhealthy liver can't do any of these things. Getting liver disease treatment as soon as possible keeps you alive.

Liver Disease Treatment Experts

At UVA Health, you'll find a world-class team of hepatology specialists. We can stop your liver disease from getting worse. 

Conditions We Treat

  • Alpha-1 antitrypsin deficiency
  • Autoimmune hepatitis
  • Cirrhosis
  • Hemochromatosis
  • Hepatitis B
  • Hepatitis C
  • Hepatoma

Liver Disease Treatment

Liver Cancer Clinical Trials
Healthy Adults and Lung/Liver Cancer Patients are invited to be in a research study.

UVA Health System, Department of Radiology, seeks men and women who are healthy, and those with lung cancer or liver cancer for a research study. The purpose of the study is to improve imaging techniques of soft-tissue in the lungs and abdomen using Magnetic Resonance Imaging (MRI). The study involves a physical exam along with the MRI. Study procedures can be completed in one 1-2hour visit. Healthy volunteers must be 18-75 years old; Volunteers with lung or liver cancer must be 21-75 years old. Study-related MRI is provided free of charge.

Testing the combination of the anticancer drug durvalumab with chemotherapy (gemcitabine and cisplatin) at improving outcomes for high-risk liver cancer

The University of Virginia Comprehensive Cancer Center seeks adults ages 18 and over with high-risk resectable intrahepatic cholangiocarcinoma for a research study. The purpose of this study is to test the good and bad effects of the drug called durvalumab in combination with the chemotherapy drugs gemcitabine and cisplatin. This drug combination could shrink your cancer, but it could also cause side effects. The study doctors hope to learn if this drug combination will improve surgery outcomes in people with your type of high-risk liver cancer. The combination of gemcitabine, cisplatin, and durvalumab has been approved by the FDA as front line therapy for advanced biliary tract cancers, including intrahepatic cholangiocarcinoma. This regimen is approved by the FDA for treatment of your disease when it is advanced and cannot be removed with surgery; it is currently not routinely given before surgery. The study involves receiving the investigational drug, as well as coming in for study visits, which include exams, laboratory tests, and procedures such as having your blood drawn, imaging of your tumor, and talking to the study doctor. You will get the combination of durvalumab, gemcitabine, and cisplatin through a vein in your arm on the first day of each cycle and the chemotherapy drugs, gemcitabine and cisplatin, again on the eighth day of each cycle. Each cycle lasts 21 days. This part of the study has 4 cycles and then you will undergo surgery. After surgery there will be 4 more cycles of the drug combination, for a total of 8 cycles. After you finish your treatment, your doctor will continue to follow your condition in accordance with standard of care, with visits to the office every 3 months for the first two years after surgery, every 6 months for the following five years, and on a yearly basis thereafter. Your doctor will watch you for side effects and for surveillance. The investigational drug, durvalumab, will be provided by the study at no cost to you. All additional procedures required by the study beyond your standard care, including laboratory tests, are provided to you at no charge. Additional information can be found here: https://clinicaltrials.gov/study/NCT06050252 [email protected]

A Phase 1/2 Dose Escalation Study of CRN09682 With an Expansion Phase in Participants with Progressive Metastatic Somatostatin Receptor Type 2 (SST2)-Expressing Neuroendocrine Neoplasms (NENs) and Other SST2-Expressing Solid Tumors

Headline: A Phase 1/2 Dose Escalation Study of CRN09682 With an Expansion Phase in Participants with Progressive Metastatic Somatostatin Receptor Type 2 (SST2)-Expressing Neuroendocrine Neoplasms (NENs) and Other SST2-Expressing Solid Tumors Study Description: The University of Virginia Comprehensive Cancer Center seeks adults ages 18 and over with Progressive Metastatic Somatostatin Receptor Type 2 (SST2)-Expressing Neuroendocrine Neoplasms (NENs) and Other SST2-Expressing Solid Tumors. The purpose of this study is to evaluate the safety of an investigational drug, CRN09682, when given at different doses. CRN09682 is an investigational drug. Investigational drug means the drug is being studied in clinical studies to determine if it is safe and effective and it has not been approved for use or for sale in the market. The study involves receiving the investigational drug, as well as coming in for study visits, which include exams, laboratory tests, and procedures such as being weighed, having your blood drawn, having imaging done, and talking to the study doctor. If you choose to participate, the study will consist of three main parts: screening, study treatment, and follow-up. The screening period is where the study team will see if you are eligible for the study, and it may require more than 1 visit to complete all screening procedures. After screening, if you are deemed eligible for participation, the next step is the treatment period. You will receive the study drug directly into your vein through intravenous infusion (IV) on the first day of each 21-day treatment cycle. Each IV treatment can range from about 30 minutes to 90 minutes, or more. The number of treatment cycles you will have depends on how you tolerate or respond to the study drug or if you meet other study stopping criteria. The visit at the end of treatment will take place within 7 days after the last dose of study drug, and a safety follow-up visit will take place 30 days after stopping the study drug. If you are no longer getting treatment with the study drug and are still on the study, you will be asked to come into the site for follow-up visits every 3 months to check on your cancer and health status. The study drug, CRN09682, will be provided by the study sponsor at no cost to you. All additional study procedures that are beyond your standard medical care, including laboratory tests, physical examinations, and visits to the study center, are provided to you at no charge. Additional information can be found here: clinicaltrials.gov/study/NCT07129252

View All Clinical Trials

Hepatology Specialties

Fatty Liver Disease

Get treated by leaders in hepatology. We specialize in fatty liver disease, including nonalcoholic steatohepatitis (NASH).

Hepatitis

You can benefit from customized therapies. We partner with specialists in infectious disease to give you tailored treatment. Patients with hepatitis get better faster due to our advanced approach to treatment.  

Care Without Surgery

Liver scarring can cause bleeding in your GI tract. When possible, we avoid surgery. We stop the bleeding with a glue injection.

Liver Disease Treatment for Chronic Conditions

We researched a better way to control chronic, end-stage liver disease. Medicine that suppresses hepatitis can improve liver function.

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