Adolescent Hormone Study for Girls Ages 7 - 18

IRB/UVA Tracking #
Principal Investigator
Christine M Burt-Solorzano
Melissa Gilrain
Contact Email
Contact Phone
Official Trial Title
Effect of androgen receptor blockade using spironolactone on adrenal or ovarian androgen production in pubertal girls with androgen excess
Study Description

UVa Health System Center for Research in Reproduction seeks adolescent girls ages 7-18 who have symptoms of high male hormone for a research study. The purpose of the study is to see how a medication, spironolactone, effects the adrenal and ovarian production of a group of hormones known as androgens.

You may be eligible for this study if: You have high levels of male hormone. Symptoms and signs of high male hormone include irregular menstrual periods, excess hair growth, and/or high testosterone levels. Participants must not have taken contraceptive pills or hormonal medications for 3 months prior to the study.

Study involves approximately 9 study visits. Option ‘A’ has 7 outpatient visits and 2 inpatient admissions. Option ‘B’ has 9 outpatient visits. All visits will be at the Clinical Research Unit (CRU). Inpatient admission will last 16 hours each. The study will include blood draws. Volunteers will take spironolactone for three months as part of study procedures.

Study-related exams, tests and medications are provided free of charge. For more information please contact


Compensation for study completion is $500 in gift cards