Molecular Analysis for Combination Therapy Choice

UVA Tracking #
Principal Investigator
Matthew J Reilley
Contact Phone
Official Trial Title
Targeted Therapy Directed by Genetic Testing in Treating Patients With Locally Advanced or Advanced Solid Tumors,

Molecular Analysis for Combination Therapy Choice
Study Description

The University of Virginia is conducting a clinical research study sponsored by the National Cancer Institute for adults ages 18 and over. These individuals should have solid tumors that have spread to nearby tissue or lymph nodes (locally advanced) or have spread to other places in the body (advanced) and have progressed on at least one line of standard systemic therapy or have no standard treatment that has been shown to prolong overall survival may be candidates for these trials.

This ComboMATCH patient screening trial is the gateway to a coordinated set of clinical trials to study cancer treatment directed by genetic testing. Genetic tests look at the unique genetic material (genes) of patients' tumor cells. Patients with some genetic changes or abnormalities (mutations) may benefit from treatment that targets that particular genetic mutation. ComboMATCH is designed to match patients to a treatment that may work to control their tumor and may help doctors plan better treatment for patients with locally advanced or advanced solid tumors.

if you are assigned and enroll in a ComboMATCH Treatment Trial, you may need to have the following exams, tests, and procedures:
• Exam/procedures typically done prior to chemotherapy (such as physical examination and blood collection for treatment trial eligibility lab tests) if tumor screening determines you as eligible for a ComboMATCH treatment trial.
• If you are 18 years or older and enroll in a ComboMATCH Treatment Trial, a tumor tissue specimen will be required, and this may require a new biopsy for research purposes prior to initiating treatment on the treatment trial.
• Additional exams/procedures (such as physical examinations and blood collection for lab tests to monitor your condition during the study) may be required and vary across the treatment trials, which will be discussed in more detail in a separate consent form.

Study-related procedures that are being done beyond your standard of care will be provided at no cost to you or your insurance.

Additional information may be found here:……


No Compensation