Research study for adults 65 and older with Heart Failure invited to be in an exercise study

UVA Tracking #
Principal Investigator
Jason Allen
Emily Planas
Contact Email
Contact Phone
Official Trial Title
PRIME HFrEF: Novel Exercise for Older Patients with Heart Failure with Reduced Ejection Fraction
Study Description

The department of Kinesiology seeks adults ages 65 and older with Heart Failure with reduced ejection fraction (HFrEF) for a research study. The purpose of the study is to determine whether performing a hybrid Cardio-resistance training program (PRIME) results in better health outcomes than the traditional exercise training program used with individuals with heart failure. Exercise training is a proven therapy for prolonging both lifespan and health-span in individuals with HFrEF.

You may be eligible for this study if:
- You are 65 years and older
- Have been diagnosed with Heart Failure with Reduced Ejection Fraction (HFrEF)
- Are willing to participate in supervised exercise for 12 weeks.

The study involves exercise sessions (biking and lifting weights), blood draws, non-invasive cardiovascular tests, functional fitness tests, questionnaires, and optional muscle biopsies. You will be asked to participate in exercise for a total of 45-48 exercise sessions each lasting around 1 hour over a period of 12 weeks. Total study duration lasts 10 months.

Study-related testing are provided at no cost.


$400 to complete the study ($100 at each testing visit) $450 additional for optional biopsies ($150 per biopsy)