Research Study for Adults with Major Depressive Disorder (MDD)

UVA Tracking #
Principal Investigator
Anita H Clayton
Madelyn Aman
Contact Email
Contact Phone
Official Trial Title
A Phase 2, Multicenter, Randomized, Double-blind, Placebo-controlled, Parallel-arm Trial to Assess the Efficacy, Safety, and Tolerability of Centanafadine Extended-release Capsules as Monotherapy or as Adjunct to SSRI in Adult Subjects with Major Depressi
Study Description

The UVA Center for Psychiatric Clinical Research seeks adults for a research study, ages 18-65 with moderate to severe Major Depressive Disorder (MDD) with continued depressive symptoms, despite taking an antidepressant. The purpose of the study is to test the efficacy of the study medication with an existing antidepressant, compared to a placebo with the antidepressant.

Study involves taking an experimental medication or placebo, blood draws, ECGs, completing assessments, and maintaining an eDiary.
Study-related (insert exams, tests and experimental medication) provided at no cost.


Up to $75 per completed visit