Fecal Transplant for C Diff

Clostridioides difficile(C. diff) is a bacteria that causes severe diarrhea. People are usually infected after taking antibiotics for other infections. 

While antibiotics can help fight off bad bacteria, they can also kill good bacteria. When this happens, C. diff can grow and cause diarrhea, colitis and, on occasion, life-threatening infection.

Antibiotics cure some C. diff infections, but they don’t always work. 

Fecal Transplant: A New, Effective Treatment

For people with recurrent C. diff infections, UVA offers Fecal Microbiota Transplantation (FMT or fecal transplant)

How Fecal Transplant Works

Fecal transplant involves taking stool from a healthy donor and putting it in the colon of a person infected with C. diff. The healthy stool transfers beneficial, balanced bacteria to an infected patient’s colon to treat C. diff infection and prevent it from returning. 

At UVA, we do this with a colonoscope, the same device used for a routine colonoscopy.

Is FMT For You?

You may be eligible for fecal transplant if you've had either of the following:

  • Two documented episodes of mild to moderate C. diff that have not responded to 6-8 weeks of treatment with antibiotics
  • One documented episode of severe C. diff infection that permits hospital admission