Medications for Fibroids

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 At UVA, we offer a variety of medication or therapy options to treat your fibroids.

Non-Hormonal Therapy for Fibroids

For some women, discomfort and bleeding are their primary symptoms. You can manage these symptoms with anti-inflammatory medication taken during your menstrual cycle. Some medication may require a prescription.

Hormonal Therapy

There are several different hormone therapies that are currently used or studied to be used to treat uterine fibroids. Most of these drug therapies either reduce the production of estrogen or block its effects. These effects lead to a reduction in the size of the fibroid and can reduce symptoms.

Birth Control Pills

You may use birth control pills to regulate your menstrual cycle for more predictable periods or to reduce bleeding between periods. Some women can't take birth control pills because of other medical conditions, their age or if they smoke.

Birth control pills do not typically shrink fibroids. The hormones may actually cause fibroids to enlarge or lead to other side effects. 

Progesterone-Based Medications

Progesterone medications have been used to reset the uterus and temporarily stop or decrease bleeding. One way to deliver progesterone to the uterus and fibroids is through a progesterone-releasing intrauterine device. During an outpatient visit, your doctor places this device in your uterus.

These medications may not affect bleeding at all, and it does not typically shrink fibroids.


This medication decreases estrogen levels and creates an artificial menopause that stops periods and shrinks fibroids.

Lupron is often used to reduce the size of the fibroid before surgery or focused ultrasound therapy. It's also used as a bridge to menopause and is typically prescribed for three to six months.