The University of Virginia Cancer Center is conducting a clinical research study for adults ages 75 and over who have newly diagnosed Diffuse Large B cell Lymphoma (DLBCL). This study will look at the effects of the combination of two drugs: an investigational chemotherapy drug + standard drug therapy. The goal is to see if this approach is better than standard of care.

The University of Virginia Cancer Center seeks adults age 18 or older with diffuse large B-cell lymphoma for a research study. Brentuximab vedotin has been approved for treatment of certain diseases, but the purpose of the study is to see how well brentuximab vedotin, lenalidomide, and rituximab work together in treating diffuse large b-cell lymphoma and what side effects it causes.

You may be eligible for this study if: your diffuse large B-cell lymphoma has come back or did not get better with your last treatment.

The Department of Neurology Movement Disorders Clinic seeks adults with Parkinson’s disease or parkinsonism for participation in a clinical research database. The purpose of this database is to collect health information that can be used in future studies on Parkinson’s. Future studies will seek to better understand and improve treatment for Parkinson’s. The database will pool health information from a large number of people with Parkinson’s over time.

UVa Cancer Center seeks people ages 50-75 who have been diagnosed with a pancreatic cyst by imaging or EUS in the past 6 months for a research study. The purpose of the study is to compare two standard methods of patient surveillance to determine which surveillance schedule is better for the patient.
• Both standard methods of surveillance include imaging such as MRI or CT scans, which are standard of care, as well as endoscopic ultrasound (also standard), if prompted by results of images to better visualize the cyst.

The UVA Center for Leading Edge Addiction Research or CLEAR clinic is seeking men and women ages 21 and older who want to reduce their alcohol consumption to participate in a research study to test the effectiveness of an investigational medication. The purpose of the study is to see if the drug oxytocin is effective in reducing craving for alcohol and, therefore, minimizing or eliminating alcohol usage.

The Diet and Nutrition (DAN) Lab seeks healthy adults ages 20 – 40 who are slightly overweight for a research study. The purpose of the study is to assess if two weeks of eating a keto diet changes disease risk factors.

Phase 1-2 Study Investigating Safety, Tolerability, Pharmacokinetics and Preliminary Antitumor Activity of Anti-TIM-3 Monoclonal Antibody BGB-A425 in Combination with Anti-PD-1 Monoclonal Antibody Tislelizumab in Patients with Advanced Solid Tumors

Trial ID = IRB Number

Trial Title –Automatically pulled from IRB Online – no need to complete this section
PI Name: Automatically pulled from IRB Online – no need to complete this section

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The University of Virginia Comprehensive Cancer Center is conducting a clinical research study for patients who are adults with CD-123 positive acute myeloid leukemia (AML), myelofibrosis (MF) or chronic myelomonocytic leukemia (CML) who have received an allogeneic stem cell treatment (HSCT). The purpose of this study is to learn more about the safety of a drug called tagraxofusp in this population and to gain some information on whether it may help to prevent relapse.

The Division of Infectious Diseases and International Health seeks adults age 18 and older with nontuberculosis-mycobacterium (NTM) lung disease for an observational research study. The purpose of the study is to find out more about nontuberculous mycobacteria, how to treat patients with NTM, and the importance of NTM in the home environment.

Dr. Rita Basu and her team at the University of Virginia, Endocrinology seek Adults, Women, Men and Adolescents ages 15-55 normal weight and overweight people without diabetes who previously either tested positive for COVID-19 or not tested positive for COVID-19 and are vaccinated or unvaccinated for COVID – 19 for a research study.

The purpose of the study is to understand whether infection with COVID-19 increases the long-term risk of developing diabetes