UVA Health System, Department of Internal Medicine, Division of Endocrinology is conducting a clinical research study. We want to learn more about how exercise training and an investigational drug that controls blood sugar, affect blood vessels in skeletal and cardiac muscle. You may be eligible if you are 21-60 years of age and have 3 of the 4 following characteristics: 1) overweight; 2) high blood pressure; 3) high fasting blood sugar ( but not diabetic); and /or 4) high cholesterol. You must be a nonsmoker, a non-exerciser, and have never taken the drug Liraglutide

The UVA Cancer Center seeks adults ages 18 and over with previously untreated metastatic urothelial (bladder) cancer for a clinical trial. The purpose of this study is to evaluate a combination of 2 drugs vs standard chemotherapy in patients with metastatic urothelial cancer. Disease response and good and bad effects of the drug will be studied as part of this study. Study specific tests will be provided at no cost to you.

Additional information can be found here: https://clinicaltrials.gov/ct2/show/NCT04223856

The UVA Cancer Center seeks adults ages 18 and over who are about to undergo surgery for a gynecologic condition. The purpose of this study is to collect, store and use specimens and information from patients and their medical records for future research. The research will include studies to understand, prevent, treat and care for GYN conditions including cancer. Study specific tests will be provided at no cost to you.

The University of Virginia Cancer Center is conducting a clinical research study for patients who are adults ages 18 and over, and have low-grade serous carcinoma of the ovary or peritoneum. The purpose of this study to evaluate if the use of a hormonal drug, either by itself or by adding it to the usual chemotherapy drugs, can lower the chance of your cancer growing or spreading.

The University of Virginia Cancer Center seeks participants of any age and gender to participate in a study that will examine the safety of transplantation with unlicensed cord blood. Cord blood is blood that is taken from the umbilical cord and placenta of healthy newborn babies after childbirth. The cord blood units are provided by the National Cord Blood Program and meet the criteria for transplantation as approved by the Foundation for the Accreditation of Cellular Therapy.
Participants will be asked to remain in the study for 1 year after transplantation.

The University of Virginia Cancer Center seeks adults ages 18 or older for a database study that collects information about myelofibrosis and cell transplantation. The goal of this research is to determine if stem cell transplants are beneficial for patients with myelofibrosis.
You may be able to participate in this study if you are:
- a Medicare beneficiary,
- have myelofibrosis, and
- will receive an allogeneic stem cell transplant in the US.

By participating in this study, Medicare may pay for your stem cell transplant.

The Department of Radiation Oncology seeks women ages 18 and older with early stages of endometrial cancer for a research study. The purpose of the study is to compare two standard of care treatments for endometrial cancer on side effects, including those related to sexual dysfunction.

You may be eligible for this study if you have been diagnosed with early stage endometrial cancer and plan on receiving Vaginal Cuff Brachytherapy treatments after a hysterectomy to treat your cancer.

The University of Virginia Cancer Center seeks adults ages 18 or older for a research study that collects information about Multiple Myeloma and cell transplantation. This study will compare outcomes between patients who receive allogeneic hematopoietic cell transplantation (alloHCT) for their disease and patient who receive standard treatment. You may be able to participate in this study if you are:
- a Medicare beneficiary,
- have Stage II or III multiple myeloma, and
- will receive an allogeneic stem cell transplant in the US.

The UVA Cancer Center seeks adults over the age of 18 to participate in a research study to store blood samples in a repository for future research. A repository is like a bank, where blood samples are frozen and stored. The exact research that will be done on the stored samples is not known at this time; however, researchers may use these samples to learn more about:
• What affects transplant and cellular therapy results
• The distribution of tissue type in populations
• How to match donors and patients for bone marrow transplants

The UVA Cancer Center seeks women ages 18 and over who have high-risk locally advanced cervical cancer (LACC) for a clinical trial. This includes participants who have Stage IB2-IIB disease or more advanced stages of locally advanced cervical cancer, ie. Stage III and Stage IVA.