Clinical Trials

• Research Study for people with Type 1 Diabetes
• A Phase 2 Trial of Chemotherapy followed by Response Based Whole Ventricular & Spinal Canal Irradiation (WVSCI) for Patients with Localized Non-Germinomatous Central Nervous System Germ Cell Tumor (ACNS2021)
• A Phase 1/2 Trial of Selinexor (KPT-330) and Radiation Therapy in Newly-Diagnosed Pediatric Diffuse Intrinsic Pontine Glioma (DIPG) and High-Grade Glioma (HGG). (ACNS1821)
• Nivolumab in Combination With Chemo-Immunotherapy for the Treatment of Newly Diagnosed Primary Mediastinal B-Cell Lymphoma
• Irinotecan Hydrochloride, Temozolomide, and Dinutuximab With or Without Eflornithine in Treating Patients With Relapsed or Refractory Neuroblastoma

• Acute Leukemia
• Study for Patients with CD 123+ Acute Myeloid Leukemia (AML), Myelofibrosis (MF) or Chronic Myelomonocytic Leukemia (CML)

• Acute Lymphblastic Leukemia
• A Study Using Nivolumab, in Combination With Chemotherapy Drugs to Treat Nasopharyngeal Carcinoma (NPC)

• Adult Chronic Kidney Disease
• A randomized, double-blind, multicenter, Phase 3 study to evaluate efficacy and safety of belumosudil in combination with corticosteroids versus placebo in combination with corticosteroids in participants at least 12 years of age with newly diagnosed chronic graft versus host disease (cGVHD)

• Allergy
• Volunteers (between 18 to 40 years old) are needed for a study about asthma and the common cold.
• 18-40 year old non-smokers with asthma and/or allergies wanted for a cold study

• Artificial Pancreas
• CDT research study for individuals with Type 1 Diabetes to study the cardiovascular effects using the Tandem t:slim insulin pump with Control-IQ Technology

• Asthma
• Volunteers (between 18 to 40 years old) are needed for a study about asthma and the common cold.
• 18-40 year old non-smokers with asthma and/or allergies wanted for a cold study

• Blood Flow/Blood Circulation Studies
• Healthy Adults needed for Heart MRI study.

• Blood/tissue collection study
• UVa Health System seeks adults to donate specimens for research

• Brain Cancer
• Seeking Adults with Progressive Meningiomas
• Adults with Recurrent Glioblastoma (GBM) are Invited to Participate in a Research Study
• Study for Adults with Primary Central Nervous System Lymphoma (PCNSL)

• Brain Tumor
• Seeking Adults with Progressive Meningiomas
• Study for Adults with Primary Central Nervous System Lymphoma (PCNSL)
• A Phase 3 Randomized, Placebo-Controlled Trial Evaluating Memantine (IND# 149832) for Neurocognitive Protection in Children Undergoing Cranial Radiotherapy as Part of Treatment for Primary Central Nervous System Tumors (ACCL2031)

• Cardiovascular Health
• CDT research study for individuals with Type 1 Diabetes to study the cardiovascular effects using the Tandem t:slim insulin pump with Control-IQ Technology

• Carinoma
• Phase II Single-Arm Study of Durvalumab and Bevacizumab Following Transarterial Radioembolization Using Yttrium-90 Glass Microspheres (TheraSphere™) in Unresectable Hepatocellular Carcinoma Amenable to Locoregional Therapy

• CarT
• A Phase 3 Randomized Study Comparing Daratumumab, Bortezomib, Lenalidomide and Dexamethasone (DVRd) followed by Ciltacabtagene Autoleucel versus Daratumumab, Bortezomib, Lenalidomide and Dexamethasone (DVRd) followed by Autologous Stem Cell Transplant (ASCT) in Participants with Newly Diagnosed Multiple Myeloma who are Transplant Eligible - EMN28 – EMagine / 68284528MMY3005- CARTITUDE-6

• Cell therapy
• A Phase 3 Randomized Study Comparing Daratumumab, Bortezomib, Lenalidomide and Dexamethasone (DVRd) followed by Ciltacabtagene Autoleucel versus Daratumumab, Bortezomib, Lenalidomide and Dexamethasone (DVRd) followed by Autologous Stem Cell Transplant (ASCT) in Participants with Newly Diagnosed Multiple Myeloma who are Transplant Eligible - EMN28 – EMagine / 68284528MMY3005- CARTITUDE-6

• Cerebral Palsy
• Research study for children and adults ages 8 to 21 years old with cerebral palsy AND scoliosis

• Colorectal Cancer
• A Phase 2/3, Randomized, Open-Label Study of Maintenance GRT-C901/GRT-R902, A Neoantigen Vaccine, in Combination with Immune Checkpoint Blockade for Patients with Metastatic Colorectal Cancer

• Common Cold
• Volunteers (between 18 to 40 years old) are needed for a study about asthma and the common cold.
• 18-40 year old non-smokers with asthma and/or allergies wanted for a cold study

• Continuous Glucose Monitor
• CDT research study for individuals with Type 1 Diabetes to study the cardiovascular effects using the Tandem t:slim insulin pump with Control-IQ Technology

• COPD (Chronic Obstructive Pulmonary Disease)
• UVa Health System seeks adults to donate specimens for research
• UVA Health System, Radiology Research: How does air move in the lungs?

• Diabetes Type 1
• Effect of postprandial hyperglycemia on vasculature in DM1 and healthy adults (WBH001)
• Web-Based Information Tool (WIT) software Clinical Trial
• CDT research study for individuals with Type 1 Diabetes to study the cardiovascular effects using the Tandem t:slim insulin pump with Control-IQ Technology

• Diabetes Type 2
• Type 2 Diabetes and Overweight men and women, 30 to 55 years of age needed for research study

• EEG
• Research Study for Adults to Understand the Effect of Music on Perceived Pain Levels

• Emotions
• Research Study for Adults to Understand the Effect of Music on Perceived Pain Levels

• Focused Ultrasound Surgery
• Adults with Recurrent Glioblastoma (GBM) are Invited to Participate in a Research Study

• Glioblastoma
• Adults with Recurrent Glioblastoma (GBM) are Invited to Participate in a Research Study

• Healthy Subject Study
• Healthy Adults needed for Heart MRI study.
• UVA Health System, Radiology Research: How does air move in the lungs?
• Effect of postprandial hyperglycemia on vasculature in DM1 and healthy adults (WBH001)
• Healthy Adults and Lung/Liver Cancer Patients are invited to be in a research study.

• Hormone Studies
• Reproductive Hormone Studies
• Adolescent Hormone Study for Girls Ages 7 - 18
• Adolescent Hormone Study for Girls Ages 7 - 18

• Insulin Pump
• CDT research study for individuals with Type 1 Diabetes to study the cardiovascular effects using the Tandem t:slim insulin pump with Control-IQ Technology

• Kidney Cancer
• Comparing the outcome of immunotherapy-based drug combination therapy with or without surgery to remove the kidney in metastatic kidney cancer

• Kidney Disease
• Comparing the outcome of immunotherapy-based drug combination therapy with or without surgery to remove the kidney in metastatic kidney cancer

• Leukemia
• A Phase II Study of Reduced Dose Post Transplantation Cyclophosphamide as GvHD Prophylaxis in Adult Patients with Hematologic Malignancies Receiving HLA-Mismatched Unrelated Donor Peripheral Blood Stem Cell Transplantation

• Liver Cancer
• Healthy Adults and Lung/Liver Cancer Patients are invited to be in a research study.

• Lung Cancer
• Real-Time Monitoring and Modeling of Symptoms and Adverse Events in Lung Cancer Patients Receiving Oral Targeted Therapies for Tumors with Actionable Mutations
• Healthy Adults and Lung/Liver Cancer Patients are invited to be in a research study.
• Lung Cancer Surgical Trial
• A Phase 3, Open-Label, Randomized, Multi-Center Study of DZD9008 versus Platinum-Based Doublet Chemotherapy as First-Line Treatment for Patients with Locally Advanced or Metastatic Non-Small Cell Lung Cancer Harboring Epidermal Growth Factor Receptor Exon 20 Insertion Mutation
• A multicentre, Phase II, single-arm, interventional study of neoadjuvant durvalumab and platinum-based chemotherapy (CT), followed by either surgery and adjuvant durvalumab or chemoradiotherapy (CRT) and consolidation durvalumab, in participants with resectable or borderline resectable stage IIB-IIIB Non-small Cell Lung Cancer (NSCLC)

• Lymphomas
• A randomized, open-label study evaluating the efficacy and safety of cemacabtagene ansegedleucel in participants with minimal residual disease after response to first line therapy for large B-cell lymphoma (ALPHA3)

• Melanoma
• A Phase 3, multicenter, randomized, open-label, parallel group, treatment to assess the efficacy and safety of the lifileucel (LN-144, autologous tumor-infiltrating lymphocytes [TIL]) regimen in combination with pembrolizumab monotherapy in participants with untreated, unresectable or metastatic melanoma

• meningioma
• Seeking Adults with Progressive Meningiomas

• Metabolic Syndrome
• Inactive and Overweight men and women, 21 to 60 years of age needed for research study

• Movement Disorders
• Tremor Retrainer Software Application for Functional Tremor:Pilot Study

• MRI study
• UVA Health System, Radiology Research: How does air move in the lungs?
• Lung Imaging Study.

• Multiple Myeloma
• Study of Cell Transplantation in Medicare Multiple Myeloma Subjects

• Music
• Research Study for Adults to Understand the Effect of Music on Perceived Pain Levels

• myelofibrosis
• Study for Patients with CD 123+ Acute Myeloid Leukemia (AML), Myelofibrosis (MF) or Chronic Myelomonocytic Leukemia (CML)
• Database Study of Cell Transplant in Medicare Myelofibrosis Subjects

• Myeloma
• A Randomized Study of Daratumumab Plus Lenalidomide Versus Lenalidomide Alone as Maintenance Treatment in Patients with Newly Diagnosed Multiple Myeloma Who Are Minimal Residual Disease Positive After Frontline Autologous Stem Cell Transplant
• A Phase 2, Multicohort Open-Label Study of JNJ-68284528, a Chimeric Antigen Receptor T Cell (CAR-T) Therapy Directed Against BCMA in Subjects with Multiple Myeloma

• Neurology
• Tremor Retrainer Software Application for Functional Tremor:Pilot Study

• Outpatient Study
• Healthy Adults needed for Heart MRI study.
• Inactive and Overweight men and women, 21 to 60 years of age needed for research study
• Type 2 Diabetes and Overweight men and women, 30 to 55 years of age needed for research study

• Ovarian Cancer
• A Research Study for Adult Women with Platinum-Resistant Ovarian, Fallopian Tube or Primary Peritoneal Cancer
• A Phase 3, Randomized, Open-Label Study of Combination Therapy with Avutometinib plus Defactinib Versus Investigator’s Choice of Treatment in Patients with Recurrent Low-Grade Serous Ovarian Cancer (LGSOC)

• Overweight
• Inactive and Overweight men and women, 21 to 60 years of age needed for research study
• Type 2 Diabetes and Overweight men and women, 30 to 55 years of age needed for research study

• Pain
• Research Study for Adults to Understand the Effect of Music on Perceived Pain Levels

• Pediatric Cancers: Hodgkin's Disease
• A Randomized Phase 3 Interim Response Adapted Trial Comparing Standard Therapy With Immuno-Oncology Therapy for Children and Adults With Newly Diagnosed Stage I and II Classic Hodgkin Lymphoma (AHOD2131)

• Polycystic Ovarian Syndrome
• Reproductive Hormone Studies
• Adolescent Hormone Study for Girls Ages 7 - 18
• Adolescent Hormone Study for Girls Ages 7 - 18

• Primary Central Nervous System Lymphoma (PCNSL)
• Study for Adults with Primary Central Nervous System Lymphoma (PCNSL)

• Prostate
• A Phase 2, Randomized, Open-Label, Study of lorigerlimab with docetaxel or docetaxel alone in Participants with Metastatic Castration-Resistant Prostate Cancer
• Treating prostate cancer that has come back after surgery with apalutamide and targeted radiation based on PET imaging

• Prostate Cancer
• ) A Phase 1/2 Open-Label, Dose-Escalation and Cohort Expansion Clinical Trial to Evaluate the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of ARV-766 in Patients with Metastatic Castration-Resistant Prostate Cancer
• A Phase 2, Randomized, Open-Label, Study of lorigerlimab with docetaxel or docetaxel alone in Participants with Metastatic Castration-Resistant Prostate Cancer
• Treating prostate cancer that has come back after surgery with apalutamide and targeted radiation based on PET imaging

• Rectal Cancer
• Research study for adults with Stage II or III Rectal Cancer.

• Scoliosis
• Research study for children and adults ages 8 to 21 years old with cerebral palsy AND scoliosis
• Research study for children and adults ages 10 to 21 years old with scoliosis

• Smoking
• UVa Health System seeks adults to donate specimens for research

• Solid Tumors
• Phase 2 Trial of the Combination of the BET Inhibitor, ZEN003694 (ZEN-3694), and the PARP Inhibitor Talazoparib, in Patients with Molecularly-Selected Solid Tumors (ComBET)
• Molecular Analysis for Combination Therapy Choice

• Stem Cell Transplant
• Patients with allogeneic hematopoietic cell transplants are needed for a study to research an investigative cellular therapy to prevent life threatening viral infections compared to a placebo
• Study for Patients with CD 123+ Acute Myeloid Leukemia (AML), Myelofibrosis (MF) or Chronic Myelomonocytic Leukemia (CML)
• Research Database on Transplants and Cellular Therapies
• A phase 2, open-label, single-arm, multicohort, multicenter trial to evaluate the efficacy and safety of JCAR017 in adult subjects with relapsed or refractory indolent B-cell non-hodgkin lymphoma (NHL)
• Blood Sample Banking For Future Research
• Study of Cell Transplantation in Medicare Multiple Myeloma Subjects
• Database Study of Cell Transplant in Medicare Myelofibrosis Subjects

• Transplant
• Safety Study of Cell Transplant with Unlicensed Cord Blood (CB)

• Tremor
• Tremor Retrainer Software Application for Functional Tremor:Pilot Study

• Uterine Cancer
• A Phase 3, Randomized, Placebo-Controlled, Double-Blind, Multicenter Trial for Selinexor in Maintenance Therapy after Systemic Therapy for Patients with P53 wild-type, Advanced or Recurrent Endometrial Carcinoma

• Women's Health
• Reproductive Hormone Studies